Developing a Nitroglycerin Dose Titration Decision Support System

Event title: Developing a Nitroglycerin Dose Titration Decision Support System

Presenter: Navpreet Kamboj, RN, MScN, PhD Student, Lawrence S. Bloomberg Faculty of Nursing, University of Toronto 

Brief Description: Nitroglycerin is a first-line medication for the acute relief of chest pain. For patients requiring a continuous infusion of nitroglycerin, there is no standardized dose of nitroglycerin because the impact of the medication on blood pressure varies significantly between patients. Therefore, a nurse must manually titrate (increase or decrease) the dosage to achieve optimal titration, defined as avoiding hyper and hypotension while achieving chest pain relief in the setting of an acute coronary syndrome. However, achieving optimal titration is challenging. Navpreet’s research aims to develop a nitroglycerin dose titration decision support system called NITRO DSS that provides a forecast of future blood pressure measurements at the time of nitroglycerin dose titration. With insight into the predicted future blood pressure, nurses can adjust the current dosage to prevent hyper and hypotensive episodes, while achieving the target of chest pain relief.